Dr. Annamaria Biroccio | Molecular Biology | Best Researcher Award

IRCCS-Regina Elena National Cancer Institute | Italy

Dr. Annamaria Biroccio, PhD (Microbiology, University of Messina) is a Senior Investigator at the Regina Elena National Cancer Institute (IRE-IFO), Rome, with over two decades of experience in cancer molecular biology and telomere research. Her work focuses on elucidating the mechanisms regulating telomere function and their implications in cancer progression, alongside developing pharmacological strategies targeting telomeres for anticancer therapy. She has published extensively in high-impact journals, contributing over 115 peer-reviewed papers on telomere biology, DNA damage response, and targeted therapies. According to her CV, Dr. Biroccio holds an H-index of 44, reflecting substantial influence in the field, with more than 6124 citations across her publications. Her research leadership is underscored by principal investigator roles in major national and international grants, including AIRC, CNR, and EU FP7 programs. She is also co-owner of two patents related to telomere-targeting therapeutics for triple-negative breast cancer. In recognition of her contributions, she has received multiple awards such as the Mascia Brunelli Award and Young Investigator Award. Beyond research, Dr. Biroccio has significantly contributed to scientific training as a tutor for numerous national fellowship programs and serves on editorial boards of prominent cancer research journals

Featured Publications

Dinami, R., Petti, E., Ostano, P., Iachettini, S., Rizzo, A., Maresca, C., Zizza, P., Di Vito, S., Porru, M., D’Angelo, C., Sibilio, P., De Nicola, F., Russo, R., Di Benedetto, A., Palange, A., Fanciulli, M., Chambery, A., Gilson, E., & Biroccio, A. (2025). Multi-omics analyses integration reveals a novel TRF2–miR-181a-5p–S100A10 regulatory axis in colon cancer. Cellular and Molecular Biology Letters, 30(1), 121.

Petti, E., Di Vito, S., Dinami, R., Porru, M., Marchesi, S., Lohuis, J., Zizza, P., Iachettini, S., Salvati, E., D’Angelo, C., Rizzo, A., Maresca, C., Ascione, F., Di Benedetto, A., Buglioni, S., Sacconi, A., Ostano, P., Li, Q., Stoppacciaro, A., Leonetti, C., van Rheenen, J., Maiuri, P., Scita, G., & Biroccio, A. (2025). TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple-negative breast cancer. Cell Death & Disease, 16(1), 224.

Pirota, V., Iachettini, S., Platella, C., Zizza, P., Fracchioni, G., Di Vito, S., Carachino, A., Battistini, F., Orozco, M., Freccero, M., Biroccio, A., & Doria, F. (2025). Naphthalene diimide–naphthalimide dyads promote telomere damage by selectively targeting multimeric G-quadruplexes. Nucleic Acids Research, 53(7), gkaf301.

Russomanno, P., Zizza, P., Cerofolini, L., D’Aria, F., Iachettini, S., Di Vito, S., Amato, J., Fragai, M., Pagano, B., & Biroccio, A. (2025). Expanding the functions of KHSRP protein: Insights into DNA G-quadruplex binding. Advanced Science, 12(8), e2410086.

Pirota, V., Salvati, E., Risoldi, C., Manoli, F., Rizzo, A., Zizza, P., Biroccio, A., Freccero, M., & Manet, I. (2025). Core-extended naphthalene diimide dyads as light-up probes with targeted cytotoxicity toward tumor cells. Biomolecules, 15(2), 311.

Annamaria Biroccio | Molecular Biology | Best Researcher Award

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