Best Researcher Award
| Muriel Delepierre |
| Affiliation |
CNRS/Institut Pasteur |
| Country |
France |
| Scopus ID |
7007147075 |
| Documents |
170 |
| Citations |
7,312 |
| h-index |
45 |
| Subject Area |
Structure determination and interaction by NMR |
| Event |
World Life Science Awards |
Muriel Delepierre is a French scientist affiliated with CNRS/Institut Pasteur</strong;, recognized for her contributions to structure determination and interaction by nuclear magnetic resonance (NMR). Her research has advanced the understanding of biomolecular structures, molecular recognition processes, and protein-ligand interactions, supporting developments in structural biology, microbiology, and therapeutic research. The Best Researcher Award presented through the World Life Science Awards acknowledges sustained scholarly achievement, international research visibility, and significant contributions to the life sciences community.
Abstract
This article presents an academic overview of Muriel Delepierre and her recognition through the Best Researcher Award associated with the World Life Science Awards. Her work in NMR-based structure determination has contributed to the characterization of complex biomolecular assemblies, including proteins, carbohydrates, and microbial components relevant to infectious disease research.
Keywords
Structure determination by NMR; Biomolecular interactions; Structural biology; Protein-ligand interactions; Nuclear magnetic resonance spectroscopy; Institut Pasteur; CNRS; Molecular recognition; Life sciences research; Best Researcher Award.
Introduction
Nuclear magnetic resonance spectroscopy is one of the principal experimental techniques used for investigating the structure, dynamics, and interactions of biological macromolecules in solution. It complements X-ray crystallography and cryo-electron microscopy by providing detailed information about molecular flexibility and transient interaction states that are often inaccessible through other methods. These capabilities have made NMR an essential tool for understanding biological function at the atomic level and for supporting rational approaches to drug discovery and biomolecular engineering. [1] [2]
Research Profile
The research profile of Muriel Delepierre is characterized by interdisciplinary work spanning structural biology, biophysics, microbiology, and molecular interaction analysis. Her affiliation with CNRS/Institut Pasteur places her within a leading international environment for biomedical and life sciences research, where structural approaches are integrated with microbiological and immunological investigations.
Research Contributions
Muriel Delepierre has contributed to the development and application of NMR techniques for investigating the structure and dynamics of biomolecules in solution. Her research has addressed questions related to conformational behavior, molecular recognition, and the characterization of biologically active macromolecular complexes. These investigations are particularly valuable for systems that exhibit flexibility or transient interactions, where solution-state NMR provides unique experimental advantages. [3] [4]
- Structural characterization of proteins and glycoconjugates involved in microbial and cellular processes.
- Investigation of protein-ligand and carbohydrate-protein interactions relevant to host-pathogen recognition.
Publications
The publication record associated with Muriel Delepierre demonstrates sustained engagement with peer-reviewed research in structural biology and NMR spectroscopy. Her work has appeared in journals covering biomolecular NMR, structural biology, microbiology, and molecular biophysics. Representative areas of publication include:
Research Impact
Citation-based indicators provide evidence of the influence of a researcher’s work within the scientific community. With more than 7,000 citations and an h-index of 45, the scholarly output associated with Muriel Delepierre has achieved substantial international visibility. These indicators suggest that her publications have contributed to ongoing research in structural biology, biomolecular NMR, and host-pathogen interaction studies.
Award Suitability
The Best Researcher Award is intended to recognize sustained scientific excellence, influential scholarly contributions, and meaningful advancement of knowledge within a specialized field. Based on the available academic indicators and the documented focus on structure determination and interaction by NMR, Muriel Delepierre demonstrates several characteristics consistent with such recognition.
Conclusion
Muriel Delepierre has established a distinguished research profile in the field of structure determination and interaction by NMR. Her work has contributed to the elucidation of biomolecular structures and interaction mechanisms that are important for structural biology, microbiology, and biomedical research.
External Links
References
- Ingrilimine, a novel marine cytotoxic and apoptotic cyclic imine toxin with a high affinity and dual activity on human α7 nicotinic acetylcholine receptor. Chemosphere, 406, 144955.
https://doi.org/10.1016/j.chemosphere.2026.144955
- Cyclic imine toxins survey in coastal European shellfish samples: Bioaccumulation and mode of action of 28-O-palmitoyl ester of pinnatoxin-G. First report of portimine-A bioaccumulation. Harmful Algae, 98, 101887.
https://doi.org/10.1016/j.hal.2020.101887
- Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function. Toxicon, 167, 184–191.
https://doi.org/10.1016/j.toxicon.2019.06.013
- 2nd PSL Chemical Biology Symposium (2019): At the crossroads of chemistry and biology. ChemBioChem, 20(7),
https://doi.org/10.1002/cbic.201900092